Caryophyllene is the only common terpene that binds CB2 receptors directly — making it the most pain-relevant terpene. Look for strains where caryophyllene is the lead or co-lead terpene. Aroma: peppery, clove, slight pine.
Names that signal caryophyllene-rich profiles: OG Kush, Original Glue (GG#4), Sour Diesel, Cookies (variants), Bubba Kush, Master Kush. Pair with 1:1 CBD:THC ratio products for sustained anti-inflammatory action.
For knee, back, shoulder, post-workout muscle: topical balm with menthol or camphor additives. CB2 receptors in skin respond to topical THC + CBD without systemic absorption (no high). Best applied 2-3x daily during pain episode.
Caryophyllene-rich strains like OG Kush, Original Glue, Sour Diesel, and Bubba Kush — caryophyllene is the only common terpene that binds CB2 receptors directly (most pain-relevant). Pair with 1:1 CBD:THC ratio products + topical balms for localized pain.