From downtown Williamsport: US-15 north through Trout Run and Mansfield to the New York state line near Lawrenceville, continuing to the Bridge Street exit in Corning. ~75 miles. Trout Run, PA is a natural midpoint coffee stop.
The 3-hour round trip drives a different shopping pattern than closer PA cities. Williamsport visitors plan the trip as a small Finger Lakes overnight — shop, dinner on Market Street, hotel in Corning or Painted Post, breakfast + maybe CMOG, drive back. Cannabis must be consumed in NY before crossing back into PA.